Antiretroviral drug concentrations in semen of HIV-1 infected men
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چکیده
منابع مشابه
Antiretroviral drug concentrations in semen of HIV-1 infected men.
Because semen is a major vehicle for the sexual transmission of HIV-1, control of viral replication within the sanctuary of the male genital tract should be a goal of antiretroviral therapy. Local immune responses, virus specific factors, and the degree of viral and cellular trafficking all appear to be important in controlling viral replication and evolution. However, the most important factor...
متن کاملSemen alterations in HIV-1 infected men.
BACKGROUND Couples in whom the man is infected by human immunodeficiency virus (HIV) increasingly request assisted reproductive technology (ART) to allow safe procreation. Semen quality is critical in such situations. METHODS Semen characteristics were evaluated in 189 HIV-infected men requesting ART. At the time of semen analysis all men were healthy and 177 were receiving anti-retroviral th...
متن کاملSemen Bacterial Concentrations and HIV-1 RNA Shedding Among HIV-1–Seropositive Kenyan Men
INTRODUCTION HIV-1 is transmitted through semen from men to their sexual partners. Genital infections can increase HIV-1 RNA shedding in semen, but shedding also occurs in the absence of typical pathogens. We hypothesized that higher bacterial concentrations in semen would be associated with higher HIV-1 RNA levels. METHODS We analyzed semen samples from 42 HIV-1-seropositive Kenyan men using...
متن کاملPharmacokinetics of raltegravir in the semen of HIV-infected men.
BACKGROUND We sought to determine the pharmacokinetic disposition of raltegravir in the blood and seminal plasma of HIV-infected men. METHODS We conducted a pharmacokinetic study using a staggered sampling approach. A total of 16 HIV-infected men receiving raltegravir-based therapy were recruited into the study. Each participant provided six blood plasma and six seminal plasma samples for qua...
متن کاملAntiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1.
The majority of human immunodeficiency virus type 1 (HIV-1) infections result from seminal transmission (17, 104). The size of the viral innoculum in seminal fluid is likely the major determinant of transmissibility. Current HIV prevention strategies include comprehensive population interventions promoting condom use, early diagnosis and treatment of sexually transmitted diseases, and education...
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ژورنال
عنوان ژورنال: Sexually Transmitted Infections
سال: 2001
ISSN: 1368-4973
DOI: 10.1136/sti.77.1.4